How much effort are you willing to put in to succeed? On the seemingly endless journey to pursue fertility, how many chances will you give to the medical team?

The cover story of iVie Issue 58 features a Cool Mom who suffered from immune rejection, thrombosis issues, and strong uterine contractions. She had experienced repeated implantation failure four times at other hospitals, and the reasons remained unknown. After seven years of treatment at our hospital, she finally gave birth to a healthy baby. Her heartbreaking journey was an exploration full of difficulty, and her story is worth savoring.

Precisely filter the hidden suspects on the path of pursuing fertility by identifying their “dark history”

According to our experience, among 10 IVF clients, two to three of them have immune or thrombotic issues. How do we identify these issues immediately from the initial consultation? The “dark history”during the path of pursuing fertility is an indicator. For such clients, we conduct basic and advanced immune screening, also known as dynamic screening, to identify "suspects" in order to plan in advance. After implantation we perform three times of dynamic screening and compare the changes in relevant values ​​until we identify all the culprits.

What does "dark history" mean in terms of fertility treatment? For women aged 35-40, this means having regular unprotected sex for two years but not getting pregnant; having experiences of two miscarriages or two failed implantation also counts. For women under 35, it means having regular unprotected sex for one year but not getting pregnant.

Unique reproductive medicine, a multi-professional medical team

Before 2023, we referred all patients with “dark history” to immunology departments . This is the so-called " two-stop reproductive immunology " service . We believed that experts know best so we tried our best to provide integrated medical services. However, there is a cognitive gap/information gap between different departments. Immunology departments mainly focus on adults; therefore, their standards of parameters don't usually fit for a blastocyst which only consists of hundreds of cells. Therefore, the results weren’t satisfying. A few clients spent millions on an "immunological treatments" but still the implantations failed. The immunologists always explain, "the embryo is not good enough." However, we don’t find this explanation reasonable. For example, Cool mom had used seventeen good blastocysts in her first nine implantations , among which many with normal PGS results.

Telling the truth hurts, but not doing so hurts even more! The two-stop reproductive immunization service involves traveling between two places, which is time-consuming and inconvenient. Therefore, the "one-stop reproductive immunization" service has emerged. Some reproductive centers have begun to hire immunologists to solve the problems of time consumption and inconvenience. However, the "information gap" remains the same despite the change in name. So we start to consider, what is the best solution for our clients?

From 2016 to 2025, we have collected at least 3,000 cases . With this huge database of successful cases, Stork has redefined reproductive immunology parameters. Through having precise parameters, we have repeatedly verified its "high reproducibility" with a confidence index of up to 95%. Now, Stork becomes an globally unrivaled fertility center with every doctor specializing in three domains: reproductive medicine, reproductive immunology, and thrombosis issues.

Smart Reproduction: Big Data Redefines Precised Parameters

We are embedding these unique "parameters" into two self-developed software systems: one is "Artemis," the sperm, egg, and embryo management platform of " 4SG Lab ," and the other is the medical information platform "Hi!Stork." Through this, we share reproductive centers with similar values and welcome like-minded people from home and abroad who agree with customer success to join us.

Ending the Long-Distance Running Era: Making Wonder Woman History

I almost forgot to explain the definition of "Wonder Woman": graduating from Stork after a repeated implantation failure or more than 8 miscarriages. We have nearly 1,000 clients graduating from Stork every year, but only 1-2 of them meet this condition. And all the Wonder Women were in the transition period from "two-stop reproductive immunization" to "multi-professional" nowadays. There will be no more new "Wonder Woman" clients after 2023 .

Cool Mom's last three implantations were completed using the treatment program designed by our doctors. We didn’t give her extensive immune treatment protocol, but only  immunoglobulin (IVIG) + Humira + Atosban + three doses of Clexane 6000 daily.

We appreciate Cool Mom for giving us twelve opportunities to explore reproductive immunology, helping Stork to become a better team. For now, there’s no other fertility center like us who can confirm pregnancy earlier than the fourth day, or provide precise and timely "implantation emergency care" with multi-professional doctors. Furthermore, other fertility centers don’t usually provide such accompaniment with professionalism and warmth until your graduation.