IVF 3.0+ Transferring 1# embryo

IVF 3.0+ is a treatment that combines PGS, ERA, and auto-immune therapy. Choosing the normal embryos, transferring embryos precisely at the right time, and preventing auto-immune abortion.
Consultation
2022-06-24
Author: Dr. Ryh-Sheng Li, MD
Translator: Kayla

IVF 3.0+ is a treatment that combines PGS, ERA, and auto-immune therapy. Choosing the normal embryos, transferring embryos precisely at the right time, and preventing auto-immune abortion.

I am going to share the story of Charlotte. In the process of IVF, her auto-immune blood test was negative and turned positive afterward. But with IVF3.0+, we were able to bring her a baby with one implantation and with one embryo.

Charlotte's Story

Charlotte has a 2-year-old child when she first comes to the outpatient for IVF treatment.

She was rather young at that time compared to other patients. So I suggest that we can go step by step. She wanted to give birth sooner as she is planning to have 4 kids in the future. And because of that, she plans to freeze more embryos while she is still young to lower the risk of abnormal chromosomes with advanced maternal age. Therefore, we start the journey of IVF3.0+. 

Treatment procedure 

We did two oocytes retrieval treatments, and the result was satisfying. We got 26#and 21# oocytes with two surgery.  And in total 9# blastocysts were cultured, 5# from the first surgery and 4# from the second. And the PGS chromosome screening, 6 out of 9 are normal, with normal chromosomes.

We then arranged the ERA test, to find the perfect implantation time, her result was the majority 120-hour. 

Charlotte implanted a normal embryo with the accurately predicted implantation time.

Thinking and Choosing

What seemed to be smooth at first, but in fact, we encountered a thrilling situation in the middle.

Post-implantation pregnancy blood test, B-HCG was 985.

The auto-immune blood tests before implantation were normal. After implantation, we found that her Anti-Cardiolipin IgM turned positive. After reviewing her history of IVF, no miscarriage, gave birth with nature pregnancy, and this is her first IVF, so we decided to treat it conservatively, using oral immunomodulatory pills, and then observe as we go.

We were lucky. Over time, the effect of the immune cocktail therapy using oral drugs alone gradually came out, and the concentration of anticardiolipin antibodies became lower and lower, and finally turned negative. At pregnancy 12 weeks, the baby's heartbeat was also very good. The heartbeat and fetus size were also normal, Charlotte graduated from Stork Fertility Center.

 

Comment

Stork Fertility Center
Stork Fertility Center

IVF 3.0+ contains PGS, ERA, and auto-immune blood tests at different stages.

  • PGS can select chromosomally normal embryos, improving the chances of success with each implantation.

  • ERA can find the best time for the endometrium to transfer, thus improving the implantation rate.

  • The auto-immune blood tests performed at different stages can detect immune abnormalities earlier and assist us in early treatment before they cause miscarriage.

Charlotte's auto-immune turned positive from negative, and this is rare. This also indicates that the immune system in the body may be activated by the embryo. To avoid our body attacking the embryo and causing miscarriage, we suggest auto-immune treatment. Considering Charlotte had already given birth once, we went for a more conservative treatment, the immune cocktail therapy, by using aspirin and Plaquenil. We were lucky, our theory and direction were right. Her auto-immune date was getting better and better and finally turned negative, the baby was born healthy. 

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