Analysis of Infectious Chronic Endometritis
What is ALICE (Analysis of Infectious Chronic Endometritis)?
Chronic endometritis(CE) will lead to endometritis which is one of the reasons for infertility and under most circumstances patients do not appear with obvious symptoms.ALICE is a test that detects pathogenic bacteria and recommends adequate treatment. In traditional IVF, doctors can not diagnose the bacterias specifically, and can not prescribe the appropriate treatment.

ALICE is a diagnostic test to detect and quantify the most common 8 pathogenic bacteria causing chronic endometritis, recommending appropriate antibiotic and probiotic treatment

  • Enterobacteria (e.g. Escherichia, Klebsiella)
  • Chlamydia
  • Mycoplasma
  • Neisseria
  • Ureaplasma
  • Enterococcus
  • Streptococcus
  • Staphylococcus

※ In cases of repeated implantation failure or recurrent pregnancy loss, chronic endometritis can rise to 66%.

Who should use ALICE?
  • ALICE can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation.
  • ALICE may also be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.
How is ALICE done?
Doctors will use pipelle endometrial suction curette to go into the uterus through vagina, acquire a small amount of endometrium samples. The whole procedure takes around 30 seconds to 1 minute, it can be done with an EMMA test.